Pharmaceutical-grade, Pure DHEA
(Precursor steroid sex hormone)
Factor Four: DHEA-Forte is pharmaceutical-grade, pure dehydroepiandro-sterone - a precursor steroid sex hormone - which peaks early in life in both men and women and begins to fall significantly thereafter. Studies suggest supplementation with pure DHEA may slow the aging process. Recent research has found that DHEA supplementation in women increases natural levels of progesterone and ameliorates hot flashes. Recommended for men and women over 40 years of age.
DHEA (dehydroepiandrosterone) is considered to be a key biomarker in determining biological age in both sexes. DHEA, produced by the adrenal glands, is the only hormone that peaks early in life and starts to fall significantly thereafter, reaching a low by the age of sixty.
Who May Benefit (Lifestyle)
- Men and Women over 40 years of age.
- Individuals with low DHEA blood serum levels.
- Women following menopause and/or hysterectomy.
- Men exhibiting a family history of cardiovascular disease.
- Individuals whose diet is high in refined carbohydrates.
- Individuals desiring to boost their immune system.
- Women on oral and vaginal contraceptives.
Dosage & Directions
Men 40 to 55: Take one 25 mg tablet daily with food on a consistent basis.
Men over 55: Take two 25 mg tablets daily with food on a consistent basis.
Women over 40 or on contraceptives: Take one 25 mg tablet daily with food on a consistent basis.
Patients with low DHEA: Take two to three 25 mg tablets daily until normal DHEA level has been achieved; then reduce dosage to one tablet or follow age guidelines above.
Women in post menopause or surgical menopause: Take two tablets daily with food on a consistent basis.
Important Note: DHEA does not have a "feedback" mechanism so supplementation will not curb the body's production of this hormone. Although DHEA is a promising precursor hormone, neither science nor medicine has a full understanding of this steroid and how it metabolizes into estrogens, androgens, and other hormones. Therefore, the above recommended dosages should not be exceeded.
Contraindications & Precautions
In women, high dosage levels of DHEA can result in hirsutism (excess body hair), fatigue, anger, depression, and acne rash. High dosage levels for prolonged periods may stimulate breast cysts or uterine fibroids.
In men, high dosage levels of DHEA may contribute to prostatic hypertrophy, low energy, and aggressive anger.
The dosage levels recommended in this report are within safety tolerances and guidelines for normal DHEA usage. Never take supplements at the same time as medications. If both must be taken with food, take them at different meals.
The following substances have been determined to lower DHEA levels: corticosteroids, progesterone and other oral contraceptives, cimetidine (Tagamet), lovastatin (Mevacor), ketoconazole (Nizoral), anticonvulsants, carbamazepine, phenobarbitals, and alcohol.
Factor Four Formulation
DHEA-Forte is manufactured from the steroidal saponin diogenin and converted by a series of eight chemical reactions into pure dehydroepiandrosterone.
When a DHEA tablet is swallowed, it is absorbed from the intestinal tract into the portal vein where it is transported into the liver. Most of the DHEA is metabolized by the liver before circulating throughout the bloodstream to the rest of the body.1
When DHEA is metabolized, a chemical called sulfate is added which consists of the mineral sulfur combined with oxygen, creating DHEAS - short for DHEA-sulfate. About 90% of this steroid hormone is in the DHEAS form with the balance circulating as DHEA 2
It is important to note that DHEA is lipophilic (soluble in fat) while DHEAS is water soluble. DHEA can cross the blood-brain barrier and influence the brain whereas DHEAS cannot.3
Some manufacturers "micronize" DHEA, a process that creates smaller particles that can be absorbed from the intestines into the lymphatic system and partially bypass the liver, thus increasing the amount of "free" DHEA in the blood. Such micronization has been touted as enhancing the bioavailability of DHEA although there is very limited data supporting this claim.4
Titan Laboratories does not micronize its DHEA because (1) limited data exists regarding the impact of DHEA on the brain.5 Titan is therefore reluctant to alter or "shortcut" the natural pathway of DHEA as it is produced by the adrenals.
(2) DHEAS is consistently stable on a daily basis while free DHEA cycles throughout the day and may increase up to a hundredfold at a given moment or drop drastically under stress.6 Again, Titan is reluctant to alter the naturally occurring 90/10 percentage relationship of DHEAS to free DHEA pending further clinical studies.
DHEA is a potent steroid hormone that should be utilized with care as neither science nor medicine has a full understanding of how it metabolizes into estrogens, androgens, and other hormones.
A color brochure entitled DHEA Therapy is being circulated among health practitioners which states: "DHEA is very safe because the body knows how and where to use it for optimum health, and seems to basically ignore the DHEA if it doesn't need it. "This statement is highly misleading!
No long term studies on humans have been conducted using this steroid nor do medical practitioners fully agree as to the dosage levels considered to be safe or effective.
What is known is that DHEA therapy is not suitable nor necessary for patients under 40 years of age unless low DHEA blood serum levels are confirmed. Further, DHEA appears to be of little benefit in promoting weight loss nor is it effective for muscle enhancement in those under 40 years of age, two areas in which DHEA has been heavily touted by unscrupulous promoters.
This Report has been prepared for client use to separate clinical facts from media hype regarding DHEA therapy.
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